Endocrine Abstracts

Up-to-date, there have been 7 case reports of hypomagnesaemia associated with hypocalcaemia and hypokalaemia in patients on long-term treatment with proton-pump inhibitors (PPIs). The suggestion is that these reports present a tip of an iceberg in clinical practice. Inspired by a case of severe symptomatic electrolyte loss, which was corrected by discontinuation of PPIs, we performed an audit of a potential relationship between hypomagnesaemia and PPIs in our hospital.<p c...

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

Serum alkaline phophatase (ALP) may be released from various sources, including liver, bone, thyroid, intestine and placenta. Herein, we describe a rare case of an isolated serum ALP rise initially dismissed, and later resulting in an incidental finding of a mediastinal seminoma.A 56-year-old gentleman was referred to the Endocrinology Outpatients by his general practitioner, with a 1-month history of presumed post-viral fatig...

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

Serum alkaline phophatase (ALP) may be released from various sources, including liver, bone, thyroid, intestine and placenta. Herein, we describe a rare case of an isolated serum ALP rise initially dismissed, and later resulting in an incidental finding of a mediastinal seminoma.A 56-year-old gentleman was referred to the Endocrinology Outpatients by his general practitioner, with a 1-month history of presumed post-viral fatig...

Background: Surgery has a significant role in the management of benign thyroid disease, necessitating pre-operative evaluation and appreciation of possible complications. These include hypoparathyroidism and hypothyroidism. We compared outcomes of our benign thyroid disease patients requiring surgery to national standards set by the British Thyroid Association.Method: Outcomes for patients operated between December 2010 and December 2012 with benign dise...

A 59-year-old gentleman presented to the Medical Admission Unit with facial and ankle oedema following a dog bite. He did not have any significant past medical history. Initially, he was treated for angioedema. His oedema worsened to anasarca, blood pressure rose and was found to be hypokalaemic. Echocardiogram showed a normal left ventricular ejection fraction. Urine protein creatinine ratio was <0.5 g/24 h. Vasculitic and autoimmune screen were negative. Eight weeks late...

Hypoglycaemia is a common side effect of insulin treatment in patients with type 1 diabetes mellitus (T1DM). A 16-year old girl with T1DM presented with a recurrent hypoglycaemia, despite insulin dose reduction. Differential diagnosis included: overdose of insulin, Addison’s disease, hyperthyroidism, insulinoma and anti-insulin antibodies. She was admitted to the hospital for observation and investigations. She had a low random cortisol level, leading us to start steroids...

We report a rare case of a patient presenting with headaches and almost complete bilateral hemianopia during her third trimester of pregnancy. This lady presented with headaches and vomiting 2 years prior, with a pituitary MRI initially reporting an acute pituitary haemorrhage. This time, due to progression of her visual field defects, it was decided in a multidisciplinary meeting to perform a Caesarean section at 37 weeks and start Cabergoline post-operatively, as the patient...